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In which chronic degenerative pulmonary disease excretion of desmosine and isodesmosine is increased?

Bronchodilators are a class of drug often used in the treatment of asthma and COPD, which act on β-adrenergic receptors of the airways to induce smooth muscle relaxation. The anatomic distribution of these receptors is closely correlated to the function of each structural component of the lungs. What structural component(s) of the airway would be most affected by the use of a bronchodilator, and in what functional zone(s) are they found?

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